10 Best Nicotinamide MonoNucleotide Supplements: Reviews 2022
NMN stands for nicotinamide mononucleotide, a molecule naturally occurring in all life forms. NMN is the direct precursor of the essential molecule nicotinamide adenine dinucleotide (NAD+) and is considered a key component to increase NAD+ levels in cells.
NMN is a precursor to NAD+, or nicotinamide adenine dinucleotide, meaning it becomes NAD+ through a series of chemical transformations. NAD+ is a critical found in every cell of your body, but levels of NAD+ naturally fall with age, making it — and NMN, as a result — crucial.
However, NMN is like a large bed that movers are trying to get through a door: It doesn’t enter the cell easily. One way for NMN to enter the cell is for it to chemically transform into another molecule (called nicotinamide riboside, or NR) before it can enter the cell. NR has earned a name for itself as a highly efficient precursor to NAD+ and can enter the cell as is. NMN, meanwhile, sometimes becomes NR before entering the cell, where it chemically transforms back to NMN and then ultimately becomes NAD+.
We've learned that NR leads to NAD+ and that it also has its own pathway that bypasses various steps other NAD+ precursors have to take. In early 2019, though, new research revealed NMN might only have to become NR for certain cell types, as NMN can enter cells in the small intestine of mice. It’s unclear whether or how this will translate to humans, if at all, but it’s teed up NMN as the newer kid on the block, making many wonder: How does it stack up against NR?
NR vs NMN Molecule
Pitting NR and NMN against each other is, for now, somewhat of a moot point because the two molecules have never been studied side by side in humans. The biggest, and most obvious, difference between NMN and NR is size. NMN is simply larger than NR, meaning it often needs to be broken down to fit into the cell. NR, when compared to other NAD+ precursors (like nicotinic acid or nicotinamide) reigns supreme in efficiency.
But give NMN a new door, one it can fit through, and it’s a whole new game. This is where cellular transporters come into play. Transporters are proteins that are doors on the cell; they allow molecules to enter the cell without needing to chemically transform.
The latest research from Shin-ichiro Imai, M.D., Ph.D., a professor of developmental biology at Washington University in St. Louis, identified a transporter that allows NMN to get into the cell without converting to NR. The catch? The transporter is only on cells located in the gut of mice and only works in the presence of sodium ions. NR, however, has been shown to enter cells in the liver, muscle, and brain tissue of mouse models. (To date there is not yet evidence that these mouse studies can be extrapolated to humans) But again, the two have never been matched up against each other in a way that can truly identify one as superior to the other.
What Does NMN Supplement Do?
In numerous studies, supplementation with NMN has increased NAD+ biosynthesis, suppressed age-related adipose tissue inflammation, enhanced insulin secretion and insulin action, improved mitochondrial function, improved neuronal function in the brain, and more. Here, we look at the science behind NMN, its stability, possible pharmacokinetics, transport, function, and ability to induce biosynthesis of NAD+.15 Supplementing NMN may be an effective nutraceutical anti-aging intervention, with beneficial effects on a wide array of physiological functions.
What Foods Contain NMN?
NMN can be found naturally in broccoli, cabbage, cucumber, edamame and avocado.
NMN and COVID-19
Best NMN Supplements 2022
1. TRU Niagen NAD+ Booster Supplement
TRU Niagen NAD+ Supplements come in 3 sizes:
TRU Niagen NAD+ Supplements come in 3 sizes:
- 30 count / Serving Size: 1 Capsule once a day - Servings Per Container: 30
- 90 count / Serving Size: 1 Capsule once a day - Servings Per Container: 90
- 120 count / Serving Size: 1 Capsule once a day - Servings Per Container: 120
Amazon Ratings: 4.5 out of 5 - more than 13,000 reviews
Amazon Best Sellers: #1 in Vitamin B3 (Niacin) Supplements.
- ChromaDex markets TruNiagen, which is based on its branded Niagen ingredient, which is a form of nicotinamide riboside (NR), the form of nicotinamide that actively crosses into the cell to participate in the NAD+ pathway.
- Reduces the cellular effects of aging by elevating NAD+, a key coenzyme your body uses for healthy cellular metabolism.
- Nicotinamide Riboside for Energy, Metabolism, Vitality, Muscle Health, Healthy Aging, Cellular Repair
- Unlike NMN, our key ingredient Niagen was successfully notified two times as an NDI (New Dietary Ingredient) and reviewed as GRAS (Generally Recognized As Safe) under the United States notification programs.
Everyday Renewal
Tru Niagen takes repair down to the foundation of our health, your cells. Every day, our cells are exposed to environmental toxins, hazardous compounds, and pathogens. These environmental factors and pathogens attempt to attack our DNA. Tru Niagen helps counteract this damage by activating tiny repair enzymes called sirtuins.
Fight Daily Stressors
Things like poor diet, alcohol consumption, lack of sleep, sun-exposure, and lack of exercise can be taxing on the body. These stressors affect us on the cellular level, putting our cells into overdrive in order to repair the damage. Tru Niagen helps combat these metabolic stressors.
Fitness Support
Tru Niagen helps fuel your workout and helps you recover after. It gives you fuel by supercharging your cells—focusing on continuous energy, not jolts of energy. After your workout is over, Tru Niagen helps you recover from intense exercise by boosting NAD+, a key coenzyme needed for cellular repair.
Lasting Energy
Tru Niagen promotes natural energy production deep in your cells. There are no stimulants like caffeine added. Tru Niagen helps provide every day sustaining energy through your body's natural energy-generating mechanisms.
While this is not a scientific review I have been taking Niagen in one form or another non stop for several years. I have been gradually increasing my doses with what I can only describe as a profound effect. Without a doubt I feel younger than 46. I also think I look younger than most people my age. I certainly don't feel my age and have a ton of energy every single day. I also try to eat plenty of vegetables with lots of non meat proteins along with limited meat consumption. I am not a health nut but basically try to stay away excess sugars and processed foods whenever I can. I also do a hard bike ride once or twice a week. I think this also helps the entire aging process some.
- A phase 3 randomized controlled study published in Advanced Science in 2021 (Read More)
- A study published in the American Journal of Clinical Nutrition in 2020 (Read More)
- A clinical study published in Scientific Reports in 2019 (Read More)
- A study published in Cell Reports in 2019 (Read More)
- A study published in the American Journal of Clinical Nutrition in 2018 (Read More)
- A study published in Nature Communications in 2018 (Read More)
2. Nutricost Niacinamide
Ratings: 4.6 out of 5 - more than 11,000 reviews
Amazon Best Sellers: #2 in Vitamin B3 (Niacin) Supplements.
Niacinamide is a popular form of Vitamin B3, but without the often uncomfortable feeling known as "Niacin Flush". Vitamin B3 is most often found in meats like tuna and beef. However, in order to get a similar amount of Vitamin B3, you would have to eat large amounts of tuna and beef or other sources containing Vitamin B3.
- 240 Capsules of Niacinamide Per bottle / 1 Capsule per serving
- 500mg of Vitamin B3 (Niacinamide) Per Capsule
- No "Niacin Flush"
- Non-GMO, Gluten Free, Soy Free, and Made in a GMP Compliant, FDA Registered Facility
After a recent news article about this being a favorite supplement in Australia for sun damage protection, I asked my dermatologist about it. She said it might help prevent me getting as many 'barnacles' as she calls them. You know, those nasty, old-age, sun-damage, crunchy brown or white patches all over your body. (I have many). I'm still on my first bottle but after about two weeks the most amazing thing happened. I happened to scratch an area near one of my barnacles and it just flaked off in my hand. Since then, many more have succumbed. Not all; just some. But I'm happy. Even one less of those ugly bumps is an improvement.
3. aSquared Nutrition Nicotinamide with Resveratrol
aSquared Nutrition's maximum strength Nicotinamide supplement is enhanced with Resveratrol to promote cellular health & repair, normal NAD levels, longevity and anti-aging. Our unique formula helps your cells metabolize & synthesize nutrients more effectively to boost energy.
- 120 capsules per bottle
- 500mg of Nicotinamide per Capsule / 100mg of Resveratrol powder per Capsule
- Contains 500mg of Non-Flush vitamin B3 per vegetable capsule, and is enhanced with 100mg of Resveratrol powder (7% potency yield) to promote cellular health & repair, normal NAD levels, longevity and anti-aging.
- Made in USA
- All Natural, Non-GMO, and Vegetarian
- Third Party Tested for Quality & Purity
- Supplement Pills to Support NAD, Anti Aging Skin Cell Health & Energy
- Complex contains powerful antioxidants and anti-inflammatory properties to combat poor aging.
- Resveratrol is not suitable for people undergoing blood-thinning medication
Nicotinamide + Resveratrol Formula Benefits
- Promotes Cellular Health & Repair
- Supports DNA Health & Wellness
- Supports Longevity & Anti-Aging
- Helps Boost Energy Levels
- Supports Upregulation of Sirtuin Pathway
- Supports Normal NAD / NAD+ Levels
- Powerful Antioxidant Properties
- Helps Boost Skin & Immune Health
- Contains Anti-Inflammatory Properties
- Helps Brain Health & Cognition
This product is probably about as close as you can get to the niagen supplements, like Thorne ResveraCel, without actually containing niagen or using the patented process. Nicotinamide is a form of niacin easily processed by the body. And it contains bonus resveratrol. I've only been taking these two weeks, but I've found these supplements give me some mental boost/clarity and physical energy. My skin seems more elastic. I have less appetite (my usual tendency is to over eat) and sleep better. I've lost a couple of pounds. One side effect I get is upset stomach, but the seller/manufacturer claims this will go away with time. Overall, while these supplements are no "miracle cure," I think they are providing some benefit, and I will continue to take them. I'll reevaluate once I've made it through the first bottle.
TWO MONTH UPDATE: I still feel that I am benefiting from this product. Stomach upset has diminished. I have less joint pain. I have more energy and mental clarity. Better sleep. Skin feels younger. No additional weight loss.
Ratings: 4.5 out of 5 - more than 1,800 reviews
Amazon Best Sellers: #5 in Resveratrol Nutritional Supplements.
4. Double Wood NMN Supplement
- Made in the USA
- GMO-Free
I've been using resveratrol (Jeuness) for 3.5 years, resveratrol was discovered by Dr David Sinclair (Harvard Medical School) discovered in 1992. No longer get cold. However, I'm still get tired due to aging, I believe. And getting worse lately when I've been working hard. So I started looking and noticed Dr Sinclair's book titled Lifespan: Why We Age—and Why We Don't Have To. From which I learned NMN. Then I ordered 1 bottle of NMN (Underwood). I take 4 capsules per day. Label says you can take 2-8 pills. The first week I felt less tired, but wasn't so sure it is due to NMN or something else. The second week, I started running instead of walking, so even I'm shocked! I haven't felt so hungry and energetic for the past decade! So it has to be NMN that worked!!
While I continue using resveratrol at the same time, I feel NMN makes you feel much more energetic. Can't comment longevity yet, but possible, even with NMN.
Ratings: 4.6 out of 5 - more than 1,500 reviews
Amazon Best Sellers: #9 in Vitamin B3 (Niacin) Supplements.
Answer: NMN only needs to be refrigerated when mixed into a solution. I assume you heard Dr. Sinclair mention this and he was referring to his NMN / Walter solution he would give to mice. He was not talking about stabilized NMN powder. We have performed third party tests on this product 6-12 months after production showing it is stabilized and there is no break down in the molecule.
5. Toniiq NMN Powder
- Boost NAD+ Levels - Nicotinamide Mononucleotide Powder Supplement
- Highly Purified Form of NMN Powder
- Our NMN powder contains an unprecedented purity level of 99+% (other NMN supplements and NAD supplement products won't disclose their purity levels).
- Fully Stabilized - NMN typically needs to be kept cold (fridge or freezer) because of its short shelf life. Our NMN formula comes in a completely shelf-stable non-refrigerated form and is packaged and sold in black sealed bottles that block light, moisture, and oxygen to ensure maintained and maximum potency.
- Toniiq products are produced in a GMP-certified and NSF-approved state-of-the-art manufacturing facility right here in the USA.
- We test each batch both ourselves and through a third-party independent laboratory to ensure our ingredients contain the correct standardized level of purity and active ingredients. We also test each batch for any possible additives, contaminants, and impurities to ensure the highest level of quality.
I have been using Toniiq NMN along with Resveratrol for about 7 and a half months now. I started taking these for longevity purposes after reading about them in Lifespan. Unexpectedly, I started to see my male pattern baldness reversing about 4 months in; I was not expecting this. Based on the regrowth process speed, it appears I'll reverse 8 years of hair loss in less than a year! My barber is totally floored that hair follicles can come back to life. I can only assume the cells in the rest of my body are rejuvenating as well.
I had been taking the NMN in pill form, but the powder seems to be a much better value. It has a slight tart flavor which I actually enjoy. I've only been using this new form for a short time, but I expect to continue to see the same results.
Amazon Ratings: 4.6 out of 5 - more than 300 reviews
Amazon Best Sellers: #12 in Vitamin B3 (Niacin) Supplements.
6. Thorne Research ResveraCel (Best Nicotinamide Riboside with Resveratrol and Quercetin Phytosome)
- Each capsule contains Nicotinamide Riboside (NR) ingredient, in addition to Resveratrol, Quercetin Phytosome, and Betaine.
- The ingredients in this product are complexed with Time-Sorb, a time-release matrix.
- Supports healthy aging and helps regulate metabolism
- Resveratrol and quercetin increase the activity of sirtuins
- Betaine provides important methylation factors
- Flavors, colors, preservatives, and sweeteners derived from natural sources.
- No gluten, Genetically Modified Organisms (known as GMOs), artificial preservatives, stearates, wheat, rye, barley, eggs, or nuts. This product does not contain dairy, soy, corn, yeast, sugar, or magnesium stearate.
- No unnecessary binders, coatings, disintegrants, fillers, or lubricants (including magnesium stearate) that could impair absorption.
- Adheres to the FDA’s current Good Manufacturing Practices (cGMPs) and has the highest number of NSF Certified for Sport products which tests for more than 200 banned substances for elite athletic competitions.
My husband and I are in our 60s and have been taking these capsules for a few weeks. We both started with 2 capsules daily and experienced an increase in energy and in focus. We also both had trouble remaining asleep at night and had strange dreams. We have decreased our consumption of the capsules to one per day and have had a resolution to the sleep problems. We both continue to enjoy an increase in energy and in focus. We have reordered this Thorne product and are very satisfied with the results. It would be best to start with one capsule per day and work up from there until you find your own correct dosage.
7. Purely Beneficial NMN 500 mg
About this item
About this item
About this item
- 100% PURE & Powerful Ingredients to Promote Healthy Brain Function, Healthy Aging & much more…
- 500MG PHARMACEUTICAL GRADE NMN (Nicotinamide Mononucleotide). Manufactured in USA in a cGMP Facility
- PROMOTES HEALTH AND LONGEVITY -- Nicotinamide mononucleotide (NMN) is a derivative of the B-vitamin niacin that is known to promote health and longevity by serving as a precursor to NAD+. NAD+ is required for our longevity genes to work
- NO Additives, NO Fillers, NO Animal Products, NO Gluten, NO Artificial Ingredients, NO Harmful Preservatives, NO Inferior Ingredients, NON-GMO.
8. Peak Performance NMN supplement + Resveratrol
About this item
- Not all NMN supplements are created equal! Many supplements come with just NMN, which by itself is less effective to produce higher levels of NAD which the body needs to prevent cellular degeneration as we age. Peak Performance combines NMN with Resveratrol. Resveratrol works synergistically with NMN as it acts as an accelerator to produce better results in DNA repair.
- Anti Aging = NMN + Resveratrol! Our cells use NAD+ to produce energy and to activate proteins that repair damaged DNA. Scientists believe that the decline of NAD+ as we age results in many health-related problems. To sustain healthy levels of NAD+ we can supplement this with its precursor, nicotinamide mononucleotide (NMN) . When combined with Resveratrol this supplement becomes even more powerful. Great for cellular + DNA repair, muscle endurance and strength, vascular health and blood flow.
- What's in your supplement? - Many supplements on the market use standard formulas that may contain cheap fillers and sometimes questionable ingredients. All of our ingredients are carefully chosen and 3rd party tested for purity.
- Vegan & Allergy Free - Free Of Soy, Milk, Egg, Shellfish, Corn, Wheat & Peanuts. Contains NO Gluten or Preservatives. Manufactured Under The Highest Quality GMP Regulations and USA Standards.
- Over 400,000 Happy Customers + 1-for-1 Donation To Vitamins Angels. Peak Performance is celebrating over 400,000 happy customers and we are also very proud of our 1-for-1 donation match program. For every unit you purchase, through our partnership with the nonprofit Vitamin Angels, we will supply a child at risk of malnutrition with vitamins for 1 year! To date, we've supplied over 1 Million children with life changing Vitamins- So thank you for helping us continue this great cause!
9. Codeage Liposomal NMN + Resveratrol + Quercetin Supplement
- Liposomal Phospholipid Complex: Phospholipids sourced from non-GMO sunflower oil and containing phosphatidylcholine also feature protective liposomes, which are offered through a liposomal delivery matrix.
- NMN Stabilized Form + Resveratrol: Codeage NMN nicotinamide mononucleotide performance supplement comes in powder-filled capsules for both women and men. This nicotinamide mononucleotide stable blend has been paired with trans-resveratrol, a polyphenol extracted from the root of Japanese knotweed, also know as Polygonum cuspidatum.
- NAD Supplement Precursor & Betaine: This NAD precursor athletic fitness formulation delivers 85 mg of betaine anhydrous in each serving. Also called trimethyglycine (TMG), betaine usually consists of an amino acid derived from plants and sugar beets. NAD has been researched for its role on stem cells, telomere, and cellular energy.
- Riboflavin & Vitamin B12 with Quercetin: Codeage Liposomal NMN formula also combines two of the vitamin B complex essential vitamins as well as quercetin. This formula provides Vitamin B2 as riboflavin-5-phosphate and vitamin B12 as methylcobalamine. These essential vitamins to support the metabolism have been blended with quercetin dihydrate from Japanese sophora flowers.
- Manufactured in the USA: Codeage NMN & resveratrol vitality blend is non-GMO and manufactured in the USA in a cGMP certified facility. This liposomal nicotinamide with riboflavin supplement doesn't contain any fillers, hormones, or artificial ingredients. Third-party tested.
10. Tru Niagen Immune Support Supplement (Nicotinamide Riboside with Vitamin D, C, Zinc and Curcumin)
Ratings: 4.4 out of 5 - more than 50 reviews
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